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{recent|recent} studies have reported that MSCs are able to migrate via endothelial cells, paracellular or transcellular transport, followed by migration to injury or inflammatory brain sites.345,346 in {various|many} {injuries|traumas} and ischemic events, {like|such as} injuries to {gray matter|brain}, stroke {or|or} cerebral palsy, {absolute integrity|absolute integrity|complete integrity|complete integrity|integrity/integrity} and {efficiency|The effectiveness of BBB protection is disrupted, {allowing|which allows|which allows} MSC migration through the BBB through paracellular transport through transitional interendothelial gap formations.347 cd24 expression has been found in {modern|our|human} BM-MSCs, which are {regulated|verified|regulated} by TFP-?3,348, allowing them to {interact|combine} with activated endothelial cells through p-selectin and {proceed to|begin|engage} to bind and {active|intensive|mobile} mscs.349 {also|more|in addition|in addition/in addition}, BM-MSCs express high levels of cxcr4 and cxcr7,350,351, which {turn to|bind to|come to} integrin receptors, {such as|like|like|type} vla-4, {in order|in order} {to activate|launch|make active} the integrin-binding {process|action} and {allows|enables} cells to anchor endothelial cells, followed by the migration of MSCs through the layer of endothelial cells and the basement membrane {in a process|during} called relocation.352 {this|described} process promotes the secretion of matrix metalloproteinases (MMPs), which degrade the endothelial basement membrane, allowing BM-MSCs to enter the brain environment.353,354 BM-Moscow Time {can|get the opportunity} {also|more} {tune|regulate} the integrity of the BBB through the secretion of a tissue inhibitor of matrix metalloproteinase-3 (timp3), {which|which} has been shown to mitigate the effects of BBB disruption in traumatic brain injury.355 timp3 secretion from {Moscow|Moscow time|capital} is immediately blocked by vascular endothelial growth factor A (VEGF-a) endothelial cell breakdown, decoupling, #file_links<>C:\Users\Admin\Desktop\file\gsa+en+DR30Georgiy1705252URLBB.txt",1,N], demonstrating the potential of the BM-msc mechanism in regulating the integrity of the BBB.

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